Hearing Preservation in Guinea Pigs With Long-Standing Endolymphatic Hydrops
نویسندگان
چکیده
منابع مشابه
Triple semicircular canal occlusion in guinea pigs with endolymphatic hydrops.
HYPOTHESIS Triple semicircular canal occlusion will eliminate rotatory stimulation to the vestibular peripheral system (as it blocks endolymphatic fluid movement) and therefore release rotatory vertigo attack. This surgery is safe in ears with endolymphatic hydrops. BACKGROUND Semicircular canal occlusion has been used as an alternative treatment of intractable benign paroxysmal positional ve...
متن کاملTinnitus & early endolymphatic hydrops.
Ménière's disease with all of its clinical manifestations can be divided into two categories – those symptoms that derive from the cochlea (the anterior labyrinth) and/or those that arise from the vestibular labyrinth or the posterior part of the inner ear. The symptoms that arise from the cochlea include hearing loss, which can be fluctuant and progressive and often is, or tinnitus which can b...
متن کاملTwo-phase endolymphatic hydrops: a new dynamic guinea pig model.
The classical guinea pig model for Meniere's disease, in which endolymphatic hydrops was achieved by destruction of the endolymphatic sac and obliteration of the endolymphatic duct, is a non-physiological profound model with shortcomings in relation to Meniere's disease as seen in patients. We developed a more subtle animal model; the two-phase endolymphatic hydrops. This model is based on a co...
متن کاملEffect of Endolymphatic Hydrops on Sound Transmission in Live Guinea Pigs Measured with a Laser Doppler Vibrometer
Objective. This study aimed at describing the mechanism of hearing loss in low frequency and the different dynamic behavior of the umbo, the stapes head, and the round window membrane (RWM) between normal guinea pigs and those with endolymphatic hydrops (EH), using a laser Doppler vibrometer (LDV). Methods. Cochlear sections were stained with hematoxylin and eosin (HE) to evaluate the hydropic ...
متن کاملDifferent regulation of connexin26 and ZO-1 in cochleas of developing rats and of guinea pigs with endolymphatic hydrops.
Using confocal microscopy and morphometry, we analyzed the expression of connexin26 (Cx26) and ZO-1 in rat cochlea during the postnatal period to elucidate spatiotemporal changes in gap junctions and tight junctions during auditory development. We also studied changes in these junctions in experimental endolymphatic hydrops in the guinea pig. In the adult rat cochlear lateral wall, Cx26 was det...
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ژورنال
عنوان ژورنال: Otology & Neurotology
سال: 2011
ISSN: 1531-7129
DOI: 10.1097/mao.0b013e3182382a64